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KMID : 1216720120040010030
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Korean Journal of Gynecologic Endocrinology
2012 Volume.4 No. 1 p.30 ~ p.35
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Effect of Reproductive Factors on Bone Mineral Density in Postmenopausal Women
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Hur Jun-Young
Kang Ae-Ra
Jin Chan-Hee
Shin Jung-Ho
Kim Sun-Haeng
Yuk Jin-Sung
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Abstract
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Objectives: The aim of this study was to evaluate the relations of reproductive factors including age at menarche,
age at menopause, years since menopause, lifetime estrogen exposure, number of deliveries, and age at first and
last delivery on bone mineral density (BMD) in postmenopausal women.
Methods: Retrospective chart review was performed at Health promotion Center of Guro Hospital, Korea university
medical center, from July 2008 to October 2009. A total of 217 postmenopausal women were included. BMD was
measured at the lumbar spine and at the proximal femur using dual-energy X-ray absorptiometry (DXA).
Results: Age, years since menopause, number of deliveries and age at the last delivery were negatively associated
with lumbar spine BMD. Age, years since menopause and number of deliveries were negatively associated with femur
neck BMD. However, having the first baby at later age was associated with high femur neck BMD. After adjustment
for age and body mass index, age at the last delivery was negatively correlated with lumbar spine BMD.
However, reproductive factors were not associated with femur neck BMD.
Conclusion: The present study suggests that among various reproductive factors, years since menopause, number of
deliveries and age at the first and the last delivery were associated with BMD of postmenopausal women. After
adjustment for age and body mass index, age at the last delivery was negatively correlated with lumbar spine BMD
in postmenopausal women.
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KEYWORD
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Bone Density, Delivery, Menopause
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